Cytosolic 5′-Nucleotidase II Is a Sensor of Energy Charge and Oxidative Stress: A Possible Function as Metabolic Regulator

Cytosolic 5′-Nucleotidase II Is a Sensor of Energy Charge and Oxidative Stress: A Possible Function as Metabolic Regulator

Cytosolic 5′-nucleotidase II (NT5C2) is a highly regulated enzyme involved in the maintenance of intracellular purine and the pyrimidine compound pool. It dephosphorylates mainly IMP and GMP but is also active on AMP. This enzyme is highly expressed in tumors, and its activity correlates with a high...

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Dades bibliogràfiques
Autors principals: Rossana Pesi, Simone Allegrini, Francesco Balestri, Mercedes Garcia-Gil, Federico Cividini, Laura Colombaioni, Lars Petter Jordheim, Marcella Camici, Maria Grazia Tozzi
Format: Article
Idioma:English
Publicat: MDPI AG 2021-01-01
Col·lecció:Cells
Matèries:
Cytosolic 5′-nucleotidase II
NT5C2
energy charge
oxidative stress
AMPK
ADF
Accés en línia:https://www.mdpi.com/2073-4409/10/1/182

Internet

https://www.mdpi.com/2073-4409/10/1/182

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