Identification of unique and shared mitochondrial DNA mutations in neurodegeneration and cancer by single-cell mitochondrial DNA structural variation sequencing (MitoSV-seq)

Identification of unique and shared mitochondrial DNA mutations in neurodegeneration and cancer by single-cell mitochondrial DNA structural variation sequencing (MitoSV-seq)

Background: Point mutations and structural variations (SVs) in mitochondrial DNA (mtDNA) contribute to many neurodegenerative diseases. Technical limitations and heteroplasmy, however, have impeded their identification, preventing these changes from being examined in neurons in healthy and disease s...

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Bibliographic Details
Main Authors: Elham Jaberi, Emilie Tresse, Kirsten Grønbæk, Joachim Weischenfeldt, Shohreh Issazadeh-Navikas
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:EBioMedicine
Subjects:
Mitochondrial DNA
Neurodegeneration
Single-Cell Sequencing
Disease biomarker
Neuron
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420302437

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http://www.sciencedirect.com/science/article/pii/S2352396420302437

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