Epitope Capsid-Incorporation: New Effective Approach for Vaccine Development for Chagas Disease

Epitope Capsid-Incorporation: New Effective Approach for Vaccine Development for Chagas Disease

Background: Previously we reported that a hexon-modified adenovirus (Ad) vector containing the invasive neutralizing epitope of Trypanosoma cruzi (T. cruzi) trypomastigote gp83 (Ad5-gp83) provided immunoprotection against T. cruzi infection. The purpose of this work was to design an improved vaccine...

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Bibliographic Details
Main Authors: Qiana L. Matthews, Anitra L. Farrow, Girish Rachakonda, Linlin Gu, Pius Nde, Alexandre Krendelchtchikov, Siddarth Pratap, Shruti S. Sakhare, Steffanie Sabbaj, Maria F. Lima, Fernando Villalta
Format: Article
Language:English
Published: Case Western Reserve University 2016-09-01
Series:Pathogens and Immunity
Subjects:
Chagas disease
T. cruzi vaccine constructs
epitope-capsid incorporation
trypomastigote gp83 neutralizing epitope
amastigote surface protein 2 epitope
co-immunization
immunoprotection
Online Access:https://paijournal.com/index.php/paijournal/article/view/114

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https://paijournal.com/index.php/paijournal/article/view/114

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