A Novel Dipeptidyl Peptidase-4 Inhibitor DA-1229 Ameliorates Tubulointerstitial Fibrosis in Cyclosporine Nephrotoxicity in Mice

A Novel Dipeptidyl Peptidase-4 Inhibitor DA-1229 Ameliorates Tubulointerstitial Fibrosis in Cyclosporine Nephrotoxicity in Mice

Cyclosporine A (CyA) is an immunosuppressive agent that induces nephrotoxicity with long-term treatment. The roles of DPP-4 and its inhibitors in cyclosporine nephrotoxicity are not fully understood. Therefore, we investigated the effects of a novel DPP-4 inhibitor, DA-1229, on the progression of re...

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Bibliographic Details
Main Authors: Hye Sook Min, Ji Eun Lee, Jung Yeon Ghee, Young Sun Kang, Jin Joo Cha, Jee Young Han, Sang Youb Han, Dae Ryong Cha
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Life
Subjects:
cyclosporine nephrotoxicity
DPP-4
DA-1229
inflammation
fibrosis
oxidative stress
Online Access:https://www.mdpi.com/2075-1729/11/3/251

Internet

https://www.mdpi.com/2075-1729/11/3/251

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