Human iPSC-Derived Retinal Organoids and Retinal Pigment Epithelium for Novel Intronic <i>RPGR</i> Variant Assessment for Therapy Suitability

Human iPSC-Derived Retinal Organoids and Retinal Pigment Epithelium for Novel Intronic <i>RPGR</i> Variant Assessment for Therapy Suitability

The <i>RPGR</i> gene encodes Retinitis Pigmentosa GTPase Regulator, a known interactor with ciliary proteins, which is involved in maintaining healthy photoreceptor cells. Variants in <i>RPGR</i> are the main contributor to X-linked rod-cone dystrophy (RCD), and <i>RPGR...

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Bibliographic Details
Main Authors: Fidelle Chahine Karam, To Ha Loi, Alan Ma, Benjamin M. Nash, John R. Grigg, Darshan Parekh, Lisa G. Riley, Elizabeth Farnsworth, Bruce Bennetts, Anai Gonzalez-Cordero, Robyn V. Jamieson
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Journal of Personalized Medicine
Subjects:
<i>RPGR</i>
inherited retinal disease
rod-cone dystrophy
ciliopathy
iPSC
retinal organoids
Online Access:https://www.mdpi.com/2075-4426/12/3/502

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https://www.mdpi.com/2075-4426/12/3/502

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