Annexin A7 mediates lysosome repair independently of ESCRT-III

Annexin A7 mediates lysosome repair independently of ESCRT-III

Lysosomes are crucial organelles essential for various cellular processes, and any damage to them can severely compromise cell viability. This study uncovers a previously unrecognized function of the calcium- and phospholipid-binding protein Annexin A7 in lysosome repair, which operates independentl...

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Bibliographic Details
Main Authors: Malene Laage Ebstrup, Stine Lauritzen Sønder, Ditte Louise Fogde, Anne Sofie Busk Heitmann, Tiina Naumanen Dietrich, Catarina Dias, Marja Jäättelä, Kenji Maeda, Jesper Nylandsted
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
lysosome membrane repair
lysosomal integrity
lysosomal membrane permeabilization
Annexin A7
endosomal sorting complexes required for transport III (ESCRT-III)
L-Leucyl-L-Leucine O-methyl ester (LLOMe)
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1211498/full

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https://www.frontiersin.org/articles/10.3389/fcell.2023.1211498/full

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