Structure-activity relationship and target investigation of 2-aryl quinolines with nematocidal activity

Structure-activity relationship and target investigation of 2-aryl quinolines with nematocidal activity

Within the context of our anthelmintic discovery program, we recently identified and evaluated a quinoline derivative, called ABX464 or obefazimod, as a nematocidal candidate; synthesised a series of analogues which were assessed for activity against the free-living nematode Caenorhabditis elegans;...

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Bibliographic Details
Main Authors: Harrison T. Shanley, Aya C. Taki, Nghi Nguyen, Tao Wang, Joseph J. Byrne, Ching-Seng Ang, Michael G. Leeming, Shuai Nie, Nicholas Williamson, Yuanting Zheng, Neil D. Young, Pasi K. Korhonen, Andreas Hofmann, Bill C.H. Chang, Tim N.C. Wells, Cécile Häberli, Jennifer Keiser, Abdul Jabbar, Brad E. Sleebs, Robin B. Gasser
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Anthelmintics
Drug discovery
Haemonchus contortus
Target identification
Thermal proteome profiling
In silico docking
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320724000034

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http://www.sciencedirect.com/science/article/pii/S2211320724000034

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