Synaptic scaling of corticostriatal circuits underlies hyperactivity in GABA Transporter-1 deficient mice

Synaptic scaling of corticostriatal circuits underlies hyperactivity in GABA Transporter-1 deficient mice

Summary: Homeostatic synaptic scaling entails adjustment of synaptic strength on a cell to prolonged changes of neuronal activity, which is postulated to participate in neuropsychiatric disorders in vivo. Here, we find that sustained elevation in ambient GABA levels, by either genetic deletion or ph...

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Bibliographic Details
Main Authors: Yan-Jiao Wu, Xin Yi, Xue Gu, Qi Wang, Qin Jiang, Ying Li, Michael X. Zhu, Jianqing Ding, Wei-Guang Li, Tian-Le Xu
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:iScience
Subjects:
Genetics
Molecular biology
Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223003991

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http://www.sciencedirect.com/science/article/pii/S2589004223003991

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