Targeting thrombospondin-2 retards liver fibrosis by inhibiting TLR4-FAK/TGF-β signaling

Targeting thrombospondin-2 retards liver fibrosis by inhibiting TLR4-FAK/TGF-β signaling

Background & Aims: Thrombospondin-2 (THBS2) expression is associated with liver fibrosis regardless of etiology. However, the role of THBS2 in the pathogenesis of liver fibrosis has yet to be elucidated. Methods: The in vivo effects of silencing Thbs2 in hepatic stellate cells (HSCs) were ex...

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Bibliographic Details
Main Authors: Ning Zhang, Xiaoning Wu, Wen Zhang, Yameng Sun, Xuzhen Yan, Anjian Xu, Qi Han, Aiting Yang, Hong You, Wei Chen
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:JHEP Reports
Subjects:
extracellular matrix
metabolic dysfunction-associated steatohepatitis
smooth muscle α-actin promoter
myofibroblast tropism
cirrhosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555924000156

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http://www.sciencedirect.com/science/article/pii/S2589555924000156

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