Targeting mitochondria: restoring the antitumor efficacy of exhausted T cells

Targeting mitochondria: restoring the antitumor efficacy of exhausted T cells

Abstract Immune checkpoint blockade therapy has revolutionized cancer treatment, but resistance remains prevalent, often due to dysfunctional tumor-infiltrating lymphocytes. A key contributor to this dysfunction is mitochondrial dysfunction, characterized by defective oxidative phosphorylation, impa...

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Bibliographic Details
Main Authors: Mei-Qi Yang, Shu-Ling Zhang, Li Sun, Le-Tian Huang, Jing Yu, Jie-Hui Zhang, Yuan Tian, Cheng-Bo Han, Jie-Tao Ma
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Molecular Cancer
Subjects:
Mitochondria
T cell exhaustion
Mitochondria metabolism
Mitochondrial dynamics
Epigenetics
Cancer immunotherapy
Online Access:https://doi.org/10.1186/s12943-024-02175-9

Internet

https://doi.org/10.1186/s12943-024-02175-9

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