Aging-Dependent Altered Transcriptional Programs Underlie Activity Impairments in Human C9orf72-Mutant Motor Neurons

Aging-Dependent Altered Transcriptional Programs Underlie Activity Impairments in Human C9orf72-Mutant Motor Neurons

Amyotrophic Lateral Sclerosis (ALS) is an incurable neurodegenerative disease characterized by dysfunction and loss of upper and lower motor neurons (MN). Despite several studies identifying drastic alterations affecting synaptic composition and functionality in different experimental models, the sp...

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Bibliographic Details
Main Authors: Daniel Sommer, Sandeep Rajkumar, Mira Seidel, Amr Aly, Albert Ludolph, Ritchie Ho, Tobias M. Boeckers, Alberto Catanese
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
hiPSC
ALS (amyotrophic lateral sclerosis)
motor neuron (MN)
synapse
transcriptomic (RNA-Seq)
neuronal excitability
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.894230/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.894230/full

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