Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells.

Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells.

Alkylating agents are widely used chemotherapeutics in the treatment of many cancers, including leukemia, lymphoma, multiple myeloma, sarcoma, lung, breast and ovarian cancer. Melphalan is the most commonly used chemotherapeutic agent against multiple myeloma. However, despite a 70-80% initial respo...

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Bibliographic Details
Main Authors: Kamila Anna Zub, Mirta Mittelstedt Leal de Sousa, Antonio Sarno, Animesh Sharma, Aida Demirovic, Shalini Rao, Clifford Young, Per Arne Aas, Ida Ericsson, Anders Sundan, Ole Nørregaard Jensen, Geir Slupphaug
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4358942?pdf=render

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http://europepmc.org/articles/PMC4358942?pdf=render

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