Effects and mechanism of dexmedetomidine on neuronal cell injury induced by hypoxia-ischemia

Effects and mechanism of dexmedetomidine on neuronal cell injury induced by hypoxia-ischemia

Abstract Background The present study aims to investigate the protective effects of dexmedetomidine (DMED) on hypoxia ischemia injury induced by oxygen and glucose deprivation (OGD) in PC12 and primary neuronal cells. Methods PC12 cells exposed to OGD was used to establish ischemia model. The OGD-in...

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Bibliographic Details
Main Authors: Ya-Jun Liu, Duan-Yu Wang, Yong-Jian Yang, Wei-Fu Lei
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Anesthesiology
Subjects:
Dexmedetomidine
PC12 cells
Apoptosis
Oxidative stress
Notch/NF-κB pathway
Online Access:http://link.springer.com/article/10.1186/s12871-017-0413-4

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http://link.springer.com/article/10.1186/s12871-017-0413-4

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