Disentangling PTEN-cooperating tumor suppressor gene networks in cancer
We have recently performed a whole-body, genome-wide screen in mice using a single-copy inactivating transposon for the identification of Pten (phosphatase and tensin homolog)-cooperating tumor suppressor genes (TSGs). We identified known and putative TSGs in multiple cancer types and validated the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-07-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2017.1325550 |
| _version_ | 1797677166301806592 |
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| author | Jorge de la Rosa Julia Weber Roland Rad Allan Bradley Juan Cadiñanos |
| author_facet | Jorge de la Rosa Julia Weber Roland Rad Allan Bradley Juan Cadiñanos |
| author_sort | Jorge de la Rosa |
| collection | DOAJ |
| description | We have recently performed a whole-body, genome-wide screen in mice using a single-copy inactivating transposon for the identification of Pten (phosphatase and tensin homolog)-cooperating tumor suppressor genes (TSGs). We identified known and putative TSGs in multiple cancer types and validated the functional and clinical relevance of several promising candidates for human prostate cancer. |
| first_indexed | 2024-03-11T22:41:07Z |
| format | Article |
| id | doaj.art-bd1cfa077d7440de8667e9bfe9ded2cc |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:07Z |
| publishDate | 2017-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-bd1cfa077d7440de8667e9bfe9ded2cc2023-09-22T09:10:58ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562017-07-014410.1080/23723556.2017.13255501325550Disentangling PTEN-cooperating tumor suppressor gene networks in cancerJorge de la Rosa0Julia Weber1Roland Rad2Allan Bradley3Juan Cadiñanos4Wellcome Trust Genome CampusTechnische Universität MünchenWellcome Trust Genome CampusWellcome Trust Genome CampusWellcome Trust Genome CampusWe have recently performed a whole-body, genome-wide screen in mice using a single-copy inactivating transposon for the identification of Pten (phosphatase and tensin homolog)-cooperating tumor suppressor genes (TSGs). We identified known and putative TSGs in multiple cancer types and validated the functional and clinical relevance of several promising candidates for human prostate cancer.http://dx.doi.org/10.1080/23723556.2017.1325550akap13celf2pard3prostate cancerptensleeping beautytransposontumor suppressor genewaczbtb20 |
| spellingShingle | Jorge de la Rosa Julia Weber Roland Rad Allan Bradley Juan Cadiñanos Disentangling PTEN-cooperating tumor suppressor gene networks in cancer Molecular & Cellular Oncology akap13 celf2 pard3 prostate cancer pten sleeping beauty transposon tumor suppressor gene wac zbtb20 |
| title | Disentangling PTEN-cooperating tumor suppressor gene networks in cancer |
| title_full | Disentangling PTEN-cooperating tumor suppressor gene networks in cancer |
| title_fullStr | Disentangling PTEN-cooperating tumor suppressor gene networks in cancer |
| title_full_unstemmed | Disentangling PTEN-cooperating tumor suppressor gene networks in cancer |
| title_short | Disentangling PTEN-cooperating tumor suppressor gene networks in cancer |
| title_sort | disentangling pten cooperating tumor suppressor gene networks in cancer |
| topic | akap13 celf2 pard3 prostate cancer pten sleeping beauty transposon tumor suppressor gene wac zbtb20 |
| url | http://dx.doi.org/10.1080/23723556.2017.1325550 |
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