Design, Synthesis, Biological Evaluation, and Molecular Dynamics Simulation of Influenza Polymerase PB2 Inhibitors

Design, Synthesis, Biological Evaluation, and Molecular Dynamics Simulation of Influenza Polymerase PB2 Inhibitors

The PB2 subunit of the influenza RNA-dependent RNA polymerase (RdRp) has been identified as a promising target for the treatment of influenza. To expand the chemical space of the known influenza polymerase PB2 inhibitor–pimodivir (formerly VX-787) and improve its pharmacokinetic profile, two pimodiv...

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Bibliographic Details
Main Authors: Xinhong Li, Yijie Xu, Wei Li, Jinjing Che, Xu Zhao, Ruyuan Cao, Xingzhou Li, Song Li
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Molecules
Subjects:
influenza virus
antiviral
PB2 inhibitors
2,3-dihydro-imidazopyridine
molecular dynamics
MM/PBSA
Online Access:https://www.mdpi.com/1420-3049/28/4/1849

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https://www.mdpi.com/1420-3049/28/4/1849

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