Obesity reprograms the pulmonary polyunsaturated fatty acid-derived lipidome, transcriptome, and gene-oxylipin networks

Obesity reprograms the pulmonary polyunsaturated fatty acid-derived lipidome, transcriptome, and gene-oxylipin networks

Obesity exacerbates inflammation upon lung injury; however, the mechanisms by which obesity primes pulmonary dysregulation prior to external injury are not well studied. Herein, we tested the hypothesis that obesity dysregulates pulmonary PUFA metabolism that is central to inflammation initiation an...

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Bibliographic Details
Main Authors: Rafia Virk, Nicole Buddenbaum, Abrar Al-Shaer, Michael Armstrong, Jonathan Manke, Nichole Reisdorph, Selin Sergin, Jenifer I. Fenton, E. Diane Wallace, Brandie M. Ehrmann, Hannah B. Lovins, Kymberly M. Gowdy, M Ryan Smith, Gregory J. Smith, Samir N.P. Kelada, Saame Raza Shaikh
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Journal of Lipid Research
Subjects:
arachidonic acid
high-fat diet
oxylipins
inflammation
nutrition
omega-3 fatty acids
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227522001006

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http://www.sciencedirect.com/science/article/pii/S0022227522001006

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