Ca<sup>2+</sup> Homeostasis by Plasma Membrane Ca<sup>2+</sup> ATPase (PMCA) 1 Is Essential for the Development of DP Thymocytes

Ca<sup>2+</sup> Homeostasis by Plasma Membrane Ca<sup>2+</sup> ATPase (PMCA) 1 Is Essential for the Development of DP Thymocytes

The strength of Ca<sup>2+</sup> signaling is a hallmark of T cell activation, yet the role of Ca<sup>2+</sup> homeostasis in developing T cells before expressing a mature T cell receptor is poorly understood. We aimed to unveil specific functions of the two plasma membrane Ca...

Full description

Bibliographic Details
Main Authors: David Beckmann, Kristina Langnaese, Anna Gottfried, Johannes Hradsky, Kerry Tedford, Nikhil Tiwari, Ulrich Thomas, Klaus-Dieter Fischer, Mark Korthals
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
PMCA1
PMCA4
Ca<sup>2+</sup> homeostasis
T cell development
thymocytes
DN to DP transition
Online Access:https://www.mdpi.com/1422-0067/24/2/1442

Internet

https://www.mdpi.com/1422-0067/24/2/1442

Similar Items