SMAD4 Deficiency Leads to Development of Arteriovenous Malformations in Neonatal and Adult Mice

SMAD4 Deficiency Leads to Development of Arteriovenous Malformations in Neonatal and Adult Mice

Background Hereditary hemorrhagic telangiectasia (HHT) is a rare genetic vascular disorder caused by mutations in endoglin (ENG), activin receptor‐like kinase 1 (ACVRL1; ALK1), or SMAD4. Major clinical symptoms of HHT are arteriovenous malformations (AVMs) found in the brain, lungs, visceral organs,...

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Bibliographic Details
Main Authors: Yong Hwan Kim, Se‐woon Choe, Min‐Young Chae, Suntaek Hong, S. Paul Oh
Format: Article
Language:English
Published: Wiley 2018-11-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
animal model of human disease remodeling
arteriovenous fistula
arteriovenous malformation
hereditary hemorrhagic telangiectasia
transgenic model
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.118.009514

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.118.009514

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