Assessment of vaccine herd protection in a cluster-randomised trial of Vi conjugate vaccine against typhoid fever: results of further analysisResearch in context

Assessment of vaccine herd protection in a cluster-randomised trial of Vi conjugate vaccine against typhoid fever: results of further analysisResearch in context

Summary: Background: A cluster-randomised trial of Vi-tetanus toxoid (Vi-TT) conjugate vaccine conducted in urban Bangladeshi children found a high level of direct protection by Vi-TT but no significant vaccine herd protection. We reassessed the trial using a “fried egg” analysis to evaluate whethe...

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Bibliographic Details
Main Authors: Farhana Khanam, Deok Ryun Kim, Xinxue Liu, Merryn Voysey, Virginia E. Pitzer, K. Zaman, Andrew J. Pollard, Firdausi Qadri, John D. Clemens
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:EClinicalMedicine
Subjects:
Typhoid
Typhoid conjugate vaccine
Cluster-randomised trial
Vaccine effectiveness
Fried egg design
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537023001025

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http://www.sciencedirect.com/science/article/pii/S2589537023001025

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