Paracrine- and cell-contact-mediated immunomodulatory effects of human periodontal ligament-derived mesenchymal stromal cells on CD4+ T lymphocytes

Paracrine- and cell-contact-mediated immunomodulatory effects of human periodontal ligament-derived mesenchymal stromal cells on CD4+ T lymphocytes

Abstract Background Mesenchymal stromal cells (MSCs) isolated from the periodontal ligament (hPDL-MSCs) have a high therapeutic potential, presumably due to their immunomodulatory properties. The interaction between hPDL-MSCs and immune cells is reciprocal and executed by diverse cytokine-triggered...

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Bibliographic Details
Main Authors: Christian Behm, Oliwia Miłek, Xiaohui Rausch-Fan, Andreas Moritz, Oleh Andrukhov
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Stem Cell Research & Therapy
Subjects:
Human periodontal ligament-derived mesenchymal stromal cells
TNF-α
IL-1β
Immunomodulation
CD4+ T lymphocytes
Co-culture
Online Access:https://doi.org/10.1186/s13287-024-03759-4

Internet

https://doi.org/10.1186/s13287-024-03759-4

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