In situ generation of micrometer-sized tumor cell-derived vesicles as autologous cancer vaccines for boosting systemic immune responses

In situ generation of micrometer-sized tumor cell-derived vesicles as autologous cancer vaccines for boosting systemic immune responses

Autologous tumor cell vaccines can elicit anti-tumor immune responses. Here, the authors report the design of dendritic polymer-based nanoparticles loaded with doxorubicin and the tyrosine kinase inhibitor apatinib that can induce immunogenic cell death and the in situ production of immuno-stimulato...

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Bibliographic Details
Main Authors: Yuxin Guo, Shao-Zhe Wang, Xinping Zhang, Hao-Ran Jia, Ya-Xuan Zhu, Xiaodong Zhang, Ge Gao, Yao-Wen Jiang, Chengcheng Li, Xiaokai Chen, Shun-Yu Wu, Yi Liu, Fu-Gen Wu
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33831-7

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https://doi.org/10.1038/s41467-022-33831-7

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