In situ generation of micrometer-sized tumor cell-derived vesicles as autologous cancer vaccines for boosting systemic immune responses
Autologous tumor cell vaccines can elicit anti-tumor immune responses. Here, the authors report the design of dendritic polymer-based nanoparticles loaded with doxorubicin and the tyrosine kinase inhibitor apatinib that can induce immunogenic cell death and the in situ production of immuno-stimulato...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33831-7 |
| _version_ | 1811223544831410176 |
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| author | Yuxin Guo Shao-Zhe Wang Xinping Zhang Hao-Ran Jia Ya-Xuan Zhu Xiaodong Zhang Ge Gao Yao-Wen Jiang Chengcheng Li Xiaokai Chen Shun-Yu Wu Yi Liu Fu-Gen Wu |
| author_facet | Yuxin Guo Shao-Zhe Wang Xinping Zhang Hao-Ran Jia Ya-Xuan Zhu Xiaodong Zhang Ge Gao Yao-Wen Jiang Chengcheng Li Xiaokai Chen Shun-Yu Wu Yi Liu Fu-Gen Wu |
| author_sort | Yuxin Guo |
| collection | DOAJ |
| description | Autologous tumor cell vaccines can elicit anti-tumor immune responses. Here, the authors report the design of dendritic polymer-based nanoparticles loaded with doxorubicin and the tyrosine kinase inhibitor apatinib that can induce immunogenic cell death and the in situ production of immuno-stimulatory micrometer-sized vesicles, promoting anti-tumor immune responses in preclinical models. |
| first_indexed | 2024-04-12T08:34:25Z |
| format | Article |
| id | doaj.art-bd2998047de34de1a314192dca82111c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T08:34:25Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-bd2998047de34de1a314192dca82111c2022-12-22T03:40:04ZengNature PortfolioNature Communications2041-17232022-11-0113112010.1038/s41467-022-33831-7In situ generation of micrometer-sized tumor cell-derived vesicles as autologous cancer vaccines for boosting systemic immune responsesYuxin Guo0Shao-Zhe Wang1Xinping Zhang2Hao-Ran Jia3Ya-Xuan Zhu4Xiaodong Zhang5Ge Gao6Yao-Wen Jiang7Chengcheng Li8Xiaokai Chen9Shun-Yu Wu10Yi Liu11Fu-Gen Wu12State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast UniversityState Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast UniversityState Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast UniversityState Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast UniversityState Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast UniversityState Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast UniversityState Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast UniversityState Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast UniversityState Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast UniversityState Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast UniversityState Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast UniversityState Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast UniversityState Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast UniversityAutologous tumor cell vaccines can elicit anti-tumor immune responses. Here, the authors report the design of dendritic polymer-based nanoparticles loaded with doxorubicin and the tyrosine kinase inhibitor apatinib that can induce immunogenic cell death and the in situ production of immuno-stimulatory micrometer-sized vesicles, promoting anti-tumor immune responses in preclinical models.https://doi.org/10.1038/s41467-022-33831-7 |
| spellingShingle | Yuxin Guo Shao-Zhe Wang Xinping Zhang Hao-Ran Jia Ya-Xuan Zhu Xiaodong Zhang Ge Gao Yao-Wen Jiang Chengcheng Li Xiaokai Chen Shun-Yu Wu Yi Liu Fu-Gen Wu In situ generation of micrometer-sized tumor cell-derived vesicles as autologous cancer vaccines for boosting systemic immune responses Nature Communications |
| title | In situ generation of micrometer-sized tumor cell-derived vesicles as autologous cancer vaccines for boosting systemic immune responses |
| title_full | In situ generation of micrometer-sized tumor cell-derived vesicles as autologous cancer vaccines for boosting systemic immune responses |
| title_fullStr | In situ generation of micrometer-sized tumor cell-derived vesicles as autologous cancer vaccines for boosting systemic immune responses |
| title_full_unstemmed | In situ generation of micrometer-sized tumor cell-derived vesicles as autologous cancer vaccines for boosting systemic immune responses |
| title_short | In situ generation of micrometer-sized tumor cell-derived vesicles as autologous cancer vaccines for boosting systemic immune responses |
| title_sort | in situ generation of micrometer sized tumor cell derived vesicles as autologous cancer vaccines for boosting systemic immune responses |
| url | https://doi.org/10.1038/s41467-022-33831-7 |
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