Anhydroecgonine methyl ester (AEME), a cocaine pyrolysis product, impairs glutathione-related enzymes response and increases lipid peroxidation in the hippocampal cell culture

Anhydroecgonine methyl ester (AEME), a cocaine pyrolysis product, impairs glutathione-related enzymes response and increases lipid peroxidation in the hippocampal cell culture

Crack cocaine smokers inhale, alongside with cocaine, its pyrolysis product, anhydroecgonine methyl ester (AEME). We have previously described AEME neurotoxic effect and its additive effect when co-incubated with cocaine. Our aim was to evaluate, the effect of AEME, cocaine and AEME-cocaine combinat...

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Bibliographic Details
Main Authors: Raphael Caio Tamborelli Garcia, Larissa Lobo Torres, Livia Mendonça Munhoz Dati, Ana Paula de Melo Loureiro, Solange Castro Afeche, Maria Regina Lopes Sandoval, Tania Marcourakis
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Toxicology Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750019303683

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http://www.sciencedirect.com/science/article/pii/S2214750019303683

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