Pre-treatment with candesartan protects from cerebral ischaemia

Angiotensin II (Ang II) regulates cerebral blood flow by stimulating cerebral vasoconstriction via AT 1 receptors. In adult spontaneously hypertensive rats (SHR), the cerebrovascular autoregulatory curve is shifted to the right, in the direction of higher blood pressures, an indication of excessive...

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Bibliographic Details
Main Authors: Takeshi Ito, Yasuaki Nishimura, Juan Saavedra
Format: Article
Language:English
Published: SAGE Publications 2001-09-01
Series:Journal of the Renin-Angiotensin-Aldosterone System
Online Access:https://doi.org/10.3317/jraas.2001.024