Musashi2 contributes to the maintenance of CD44v6+ liver cancer stem cells via notch1 signaling pathway

Musashi2 contributes to the maintenance of CD44v6+ liver cancer stem cells via notch1 signaling pathway

Abstract Background Liver cancer stem cells (LCSCs) contribute to hepatocellular carcinoma (HCC) development, metastasis, and drug resistance. MSI2 and Notch1 signaling are involved in the maintenance of CSCs. However, it is unknown whether MSI2 and Notch1 are involved in the maintenance of CD44v6+...

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Bibliographic Details
Main Authors: Xiju Wang, Ronghua Wang, Shuya Bai, Si Xiong, Yawen Li, Man Liu, Zhenxiong Zhao, Yun Wang, Yuchong Zhao, Wei Chen, Timothy R. Billiar, Bin Cheng
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
CD44 variant exon 6
Musashi2
Notch1 signaling pathway
Liver cancer stem cells
Hepatocellular carcinoma
Online Access:https://doi.org/10.1186/s13046-019-1508-1

Internet

https://doi.org/10.1186/s13046-019-1508-1

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