Unfractionated heparin attenuated histone-induced pulmonary endothelial glycocalyx injury through Ang/Tie2 pathway

Unfractionated heparin attenuated histone-induced pulmonary endothelial glycocalyx injury through Ang/Tie2 pathway

Abstract Purpose This study aimed to investigate the involvement of angiopoietin (Ang)/Tie2 pathway in mediating pulmonary endothelial glycocalyx injury in histone-induced acute lung injury in mice, and the protective mechanism of unfractionated heparin (UFH). Methods Twenty-four male C57BL/6 mice (...

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Bibliographic Details
Main Authors: Jia Yin, Yawen Chi, Danyan Liu, Xinghua Li, Xu Li
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Inflammation
Subjects:
Histone
Glycocalyx
Unfractionated heparin
Angiopoietin
Online Access:https://doi.org/10.1186/s12950-025-00437-x

Internet

https://doi.org/10.1186/s12950-025-00437-x

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