M3814, a DNA-PK Inhibitor, Modulates ABCG2-Mediated Multidrug Resistance in Lung Cancer Cells

M3814, a DNA-PK Inhibitor, Modulates ABCG2-Mediated Multidrug Resistance in Lung Cancer Cells

M3814, also known as nedisertib, is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor under phase 2 clinical trials. ABCG2 is a member of the ATP-binding cassette (ABC) transporter family that is closely related to multidrug resistance (MDR) in cancer treatment. In this study, w...

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Bibliographic Details
Main Authors: Zhuo-Xun Wu, Zheng Peng, Yuqi Yang, Jing-Quan Wang, Qiu-Xu Teng, Zi-Ning Lei, Yi-Ge Fu, Ketankumar Patel, Lili Liu, Lizhu Lin, Chang Zou, Zhe-Sheng Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Oncology
Subjects:
ATP-binding cassette (ABC) transporter
M3814
nedisertib
ABCG2
multidrug resistance (MDR)
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00674/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00674/full

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