Hypothyroidism reduces the risk of lung cancer through oxidative stress response and the PI3K/Akt signaling pathway: An RNA-seq and Mendelian randomization study

Hypothyroidism reduces the risk of lung cancer through oxidative stress response and the PI3K/Akt signaling pathway: An RNA-seq and Mendelian randomization study

Hypothyroidism has been suggested to play a role in tumor progression. However, the causal association between hypothyroidism and lung cancer remains unknow. To elucidate the potential association between hypothyroidism and lung cancer risk, we employ a Mendelian randomization (MR) approach. MR was...

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Bibliographic Details
Main Authors: Wei Liu, Fei-Hang Zhi, Shao-Yi Zheng, Hao-Shuai Yang, Xi-Jie Geng, Hong-He Luo, Yan-Fen Feng, Yi-Yan Lei
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Heliyon
Subjects:
Hypothyroidism
Oxidative stress
PI3K/Akt signaling
Lung cancer
Mendelian randomization analysis
Transcriptome analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023098699

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http://www.sciencedirect.com/science/article/pii/S2405844023098699

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