5-Azacytidine-Mediated Modulation of the Immune Microenvironment in Murine Acute Myeloid Leukemia

5-Azacytidine-Mediated Modulation of the Immune Microenvironment in Murine Acute Myeloid Leukemia

Cancer cells accumulate epigenetic modifications that allow escape from intrinsic and extrinsic surveillance mechanisms. In the case of acute myeloid leukemias (AML) and myelodysplastic syndromes, agents that disrupt chromatin structure, namely hypomethylating agents (HMAs), have shown tremendous pr...

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Bibliographic Details
Main Authors: Nancy D. Ebelt, Edwin R. Manuel
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cancers
Subjects:
hematologic malignancies
acute myeloid leukemia
hypomethylating agents
5-azacytidine
resistance
relapse
Online Access:https://www.mdpi.com/2072-6694/15/1/118

Internet

https://www.mdpi.com/2072-6694/15/1/118

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