Spectrophotometric Investigations of Charge Transfer Complexes of Tyrosine Kinase Inhibitors with Iodine as a σ-Electron Acceptor: Application to Development of Universal High-Throughput Microwell Assay for Their Determination in Pharmaceutical Formulations

Spectrophotometric Investigations of Charge Transfer Complexes of Tyrosine Kinase Inhibitors with Iodine as a σ-Electron Acceptor: Application to Development of Universal High-Throughput Microwell Assay for Their Determination in Pharmaceutical Formulations

<i>Background and Objective</i>: Tyrosine kinase inhibitors (TKIs) are used for the treatment of different types of cancers. The current study describes, for the first time, the ultraviolet-visible spectrophotometric investigation of charge transfer complexes (CTCs) of seven TKIs, as ele...

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Bibliographic Details
Main Authors: Ibrahim A. Darwish, Hany W. Darwish, Awadh M. Ali, Halah S. Almutairi
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Medicina
Subjects:
tyrosine kinase inhibitors
Iodine
charge-transfer complex
96-Microwell spectrophotometric assay
high-throughput analysis
Online Access:https://www.mdpi.com/1648-9144/59/4/775

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https://www.mdpi.com/1648-9144/59/4/775

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