DNA-Binding Protein A Is Actively Secreted in a Calcium-and Inflammasome-Dependent Manner and Negatively Influences Tubular Cell Survival

DNA-Binding Protein A Is Actively Secreted in a Calcium-and Inflammasome-Dependent Manner and Negatively Influences Tubular Cell Survival

DNA-binding protein A (DbpA) belongs to the Y-box family of cold shock domain (CSD) proteins that bind RNA/DNA and exert intracellular functions in cell stress, proliferation, and differentiation. Given the pattern of DbpA staining in inflammatory glomerular diseases, without adherence to cell bound...

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Bibliographic Details
Main Authors: Gregor Hoppstock, Jonathan A. Lindquist, Antonia Willems, Annika Becker, Charlotte Reichardt, Ronnie Morgenroth, Saskia Stolze, Cheng Zhu, Sabine Brandt, Peter R. Mertens
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Cells
Subjects:
cold shock domain proteins
danger signal
inflammation
innate immunity
protein secretion
Online Access:https://www.mdpi.com/2073-4409/13/20/1742

Internet

https://www.mdpi.com/2073-4409/13/20/1742

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