Development of a membrane-based Gi-CASE biosensor assay for profiling compounds at cannabinoid receptors

Development of a membrane-based Gi-CASE biosensor assay for profiling compounds at cannabinoid receptors

Introduction: The cannabinoid receptor (CBR) subtypes 1 (CB1R) and 2 (CB2R) are key components of the endocannabinoid system (ECS), playing a central role in the control of peripheral pain, inflammation and the immune response, with further roles in the endocrine regulation of food intake and energy...

Full description

Bibliographic Details
Main Authors: Morgan Scott-Dennis, Fikri A. Rafani, Yicheng Yi, Themiya Perera, Clare R. Harwood, Wolfgang Guba, Arne C. Rufer, Uwe Grether, Dmitry B. Veprintsev, David A. Sykes
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Pharmacology
Subjects:
G-protein signaling
Gαi signaling pathway
cannabinoid receptors (CBRs)
inverse agonism
BRET—bioluminescence resonance energy transfer
GPCR signalling assay
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1158091/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1158091/full

Similar Items