iMN041 is an immunotherapeutic and an effective treatment in mouse xenograft models of pancreatic cancer, renal cancer and triple negative breast cancer

iMN041 is an immunotherapeutic and an effective treatment in mouse xenograft models of pancreatic cancer, renal cancer and triple negative breast cancer

Abstract Background iMN013 (5-aza-2',2'-difluorodeoxycytidine), a DNA methyl transferase inhibitor and ribonucleotide reductase inhibitor, and its prodrug iMN041 (3',5'-di-trimethylsilyl-2',2'-difluro-5- azadeoxycytidine), have been shown to be active in mouse xenograft...

Full description

Bibliographic Details
Main Authors: Richard Daifuku, Yu Zhang, Jingjing Wang, Qingyang Gu
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Translational Medicine Communications
Subjects:
Cancer
Breast
Pancreatic
Renal
Immunotherapy
DNA methyltransferase
Online Access:https://doi.org/10.1186/s41231-024-00161-3

Internet

https://doi.org/10.1186/s41231-024-00161-3

Similar Items