Bioavailability Enhancement of Cepharanthine via Pulmonary Administration in Rats and Its Therapeutic Potential for Pulmonary Fibrosis Associated with COVID-19 Infection

Bioavailability Enhancement of Cepharanthine via Pulmonary Administration in Rats and Its Therapeutic Potential for Pulmonary Fibrosis Associated with COVID-19 Infection

Cepharanthine (CEP) has excellent anti-SARS-CoV-2 properties, indicating its favorable potential for COVID-19 treatment. However, its application is challenged by its poor dissolubility and oral bioavailability. The present study aimed to improve the bioavailability of CEP by optimizing its solubili...

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Bibliographic Details
Main Authors: Jian Li, Guangrui Chen, Zhiyun Meng, Zhuona Wu, Hui Gan, Xiaoxia Zhu, Peng Han, Taoyun Liu, Fanjun Wang, Ruolan Gu, Guifang Dou
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Molecules
Subjects:
cepharanthine
COVID-19
pulmonary delivery
anti-fibrosis
UPLC-MS/MS
bioavailability
Online Access:https://www.mdpi.com/1420-3049/27/9/2745

Internet

https://www.mdpi.com/1420-3049/27/9/2745

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