CD200-CD200R1 inhibitory signaling prevents spontaneous bacterial infection and promotes resolution of neuroinflammation and recovery after stroke

CD200-CD200R1 inhibitory signaling prevents spontaneous bacterial infection and promotes resolution of neuroinflammation and recovery after stroke

Abstract Background Ischemic stroke results in a robust inflammatory response within the central nervous system. As the immune-inhibitory CD200-CD200 receptor 1 (CD200R1) signaling axis is a known regulator of immune homeostasis, we hypothesized that it may play a role in post-stroke immune suppress...

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Bibliographic Details
Main Authors: Rodney M. Ritzel, Abdullah Al Mamun, Joshua Crapser, Rajkumar Verma, Anita R. Patel, Brittany E. Knight, Nia Harris, Nickolas Mancini, Meaghan Roy-O’Reilly, Bhanu Priya Ganesh, Fudong Liu, Louise D. McCullough
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Neuroinflammation
Subjects:
CD200R1
Microglia
Ischemic stroke
Immunosuppression
Online Access:http://link.springer.com/article/10.1186/s12974-019-1426-3

Internet

http://link.springer.com/article/10.1186/s12974-019-1426-3

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