MCM2-7 loading-dependent ORC release ensures genome-wide origin licensing

MCM2-7 loading-dependent ORC release ensures genome-wide origin licensing

Abstract Origin recognition complex (ORC)-dependent loading of the replicative helicase MCM2-7 onto replication origins in G1-phase forms the basis of replication fork establishment in S-phase. However, how ORC and MCM2-7 facilitate genome-wide DNA licensing is not fully understood. Mapping the mole...

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Bibliographic Details
Main Authors: L. Maximilian Reuter, Sanjay P. Khadayate, Audrey Mossler, Korbinian Liebl, Sarah V. Faull, Mohammad M. Karimi, Christian Speck
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-51538-9

Internet

https://doi.org/10.1038/s41467-024-51538-9

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