Effects of Fibrotic Tissue on Liver-targeted Hydrodynamic Gene Delivery

Effects of Fibrotic Tissue on Liver-targeted Hydrodynamic Gene Delivery

Hydrodynamic gene delivery is a common method for gene transfer to the liver of small animals, and its clinical applicability in large animals has been demonstrated. Previous studies focused on functional analyses of therapeutic genes in animals with normal livers and little, however, is known regar...

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Bibliographic Details
Main Authors: Yuji Kobayashi, Kenya Kamimura, Hiroyuki Abe, Takeshi Yokoo, Kohei Ogawa, Yoko Shinagawa-Kobayashi, Ryo Goto, Ryosuke Inoue, Masato Ohtsuka, Hiromi Miura, Tsutomu Kanefuji, Takeshi Suda, Masanori Tsuchida, Yutaka Aoyagi, Guisheng Zhang, Dexi Liu, Shuji Terai
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
gene therapy
hydrodynamic gene delivery
liver fibrosis
MMP13
nonviral gene delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S216225311730077X

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http://www.sciencedirect.com/science/article/pii/S216225311730077X

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