Four TRPM4 Cation Channel Mutations Found in Cardiac Conduction Diseases Lead to Altered Protein Stability

Four TRPM4 Cation Channel Mutations Found in Cardiac Conduction Diseases Lead to Altered Protein Stability

Transient receptor potential melastatin member 4 (TRPM4), a non-selective cation channel, mediates cell membrane depolarization in immune response, insulin secretion, neurological disorders, and cancer. Pathological variants in TRPM4 gene have been linked to several cardiac phenotypes such as comple...

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Bibliographic Details
Main Authors: Beatrice Bianchi, Lijo Cherian Ozhathil, Argelia Medeiros-Domingo, Michael H. Gollob, Hugues Abriel
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Physiology
Subjects:
TRPM4
protein trafficking
cycloheximide
cardiac disorders
protein stability
ion channels
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00177/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2018.00177/full

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