A Novel Therapeutic Approach With Sodium Pyruvate on Vital Signs, Acid–Base, and Metabolic Disturbances in Rats With a Combined Blast and Hemorrhagic Shock

A Novel Therapeutic Approach With Sodium Pyruvate on Vital Signs, Acid–Base, and Metabolic Disturbances in Rats With a Combined Blast and Hemorrhagic Shock

BackgroundBlast injuries from improvised explosive devices (IEDs) are known to cause blast traumatic brain injuries (bTBIs), hemorrhagic shock (HS), organ damage, mitochondrial dysfunction, and subsequent free radical production. A pre-citric acid cycle reagent, pyruvate, is suggested to improve mit...

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Bibliographic Details
Main Authors: Biswajit Saha, Geetaram Sahu, Pushpa Sharma
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Neurology
Subjects:
blast injury
hemorrhagic shock
sodium pyruvate resuscitation
shock index
metabolic acid-base disorder
pyruvate dehydrogenase complex (PDH) activity
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.938076/full

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https://www.frontiersin.org/articles/10.3389/fneur.2022.938076/full

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