SAR and QSAR modeling of a large collection of LD50 rat acute oral toxicity data

SAR and QSAR modeling of a large collection of LD50 rat acute oral toxicity data

Abstract The median lethal dose for rodent oral acute toxicity (LD50) is a standard piece of information required to categorize chemicals in terms of the potential hazard posed to human health after acute exposure. The exclusive use of in vivo testing is limited by the time and costs required for pe...

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Bibliographic Details
Main Authors: Domenico Gadaleta, Kristijan Vuković, Cosimo Toma, Giovanna J. Lavado, Agnes L. Karmaus, Kamel Mansouri, Nicole C. Kleinstreuer, Emilio Benfenati, Alessandra Roncaglioni
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Cheminformatics
Subjects:
(Q)SAR
Acute rat oral toxicity
LD50
Integrated modeling
Computational toxicology
Online Access:http://link.springer.com/article/10.1186/s13321-019-0383-2

Internet

http://link.springer.com/article/10.1186/s13321-019-0383-2

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