A novel core genome-encoded superantigen contributes to lethality of community-associated MRSA necrotizing pneumonia.

A novel core genome-encoded superantigen contributes to lethality of community-associated MRSA necrotizing pneumonia.

Bacterial superantigens (SAg) stimulate T-cell hyper-activation resulting in immune modulation and severe systemic illnesses such as Staphylococcus aureus toxic shock syndrome. However, all known S. aureus SAgs are encoded by mobile genetic elements and are made by only a proportion of strains. Here...

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Bibliographic Details
Main Authors: Gillian J Wilson, Keun Seok Seo, Robyn A Cartwright, Timothy Connelley, Olivia N Chuang-Smith, Joseph A Merriman, Caitriona M Guinane, Joo Youn Park, Gregory A Bohach, Patrick M Schlievert, W Ivan Morrison, J Ross Fitzgerald
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-10-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22022262/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22022262/?tool=EBI

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