Cross-regulome profiling of RNA polymerases highlights the regulatory role of polymerase III on mRNA transcription by maintaining local chromatin architecture

Cross-regulome profiling of RNA polymerases highlights the regulatory role of polymerase III on mRNA transcription by maintaining local chromatin architecture

Abstract Background Mammalian cells have three types of RNA polymerases (Pols), Pol I, II, and III. However, the extent to which these polymerases are cross-regulated and the underlying mechanisms remain unclear. Results We employ genome-wide profiling after acute depletion of Pol I, Pol II, or Pol...

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Bibliographic Details
Main Authors: Yongpeng Jiang, Jie Huang, Kai Tian, Xiao Yi, Haonan Zheng, Yi Zhu, Tiannan Guo, Xiong Ji
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Genome Biology
Subjects:
RNA polymerases II and III
FACT complex
Local chromatin structure
Transcription rate
Online Access:https://doi.org/10.1186/s13059-022-02812-w

Internet

https://doi.org/10.1186/s13059-022-02812-w

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