Distinct translatome changes in specific neural populations precede electroencephalographic changes in prion-infected mice.

Distinct translatome changes in specific neural populations precede electroencephalographic changes in prion-infected mice.

Selective vulnerability is an enigmatic feature of neurodegenerative diseases (NDs), whereby a widely expressed protein causes lesions in specific cell types and brain regions. Using the RiboTag method in mice, translational responses of five neural subtypes to acquired prion disease (PrD) were meas...

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Bibliographic Details
Main Authors: Lech Kaczmarczyk, Melvin Schleif, Lars Dittrich, Rhiannan H Williams, Maruša Koderman, Vikas Bansal, Ashish Rajput, Theresa Schulte, Maria Jonson, Clemens Krost, Fabio J Testaquadra, Stefan Bonn, Walker S Jackson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-08-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010747

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https://doi.org/10.1371/journal.ppat.1010747

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