Semi-PBPK Modeling and Simulation to Evaluate the Local and Systemic Pharmacokinetics of OC-01(Varenicline) Nasal Spray

Semi-PBPK Modeling and Simulation to Evaluate the Local and Systemic Pharmacokinetics of OC-01(Varenicline) Nasal Spray

This study aimed to build a nasal semi-physiologically based pharmacokinetic (PBPK) model to predict the intranasal pharmacokinetic (PK) of the OC-01(varenicline) nasal spray and accelerate the development of this drug. Based on the physiology of the human upper respiratory system, the semi-PBPK mod...

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Bibliographic Details
Main Authors: Xiaofei Wu, Fan Zhang, Mengyang Yu, Faming Ding, Jinghui Luo, Bo Liu, Yuan Li, Zhiping Li, Hongyun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Pharmacology
Subjects:
nasal spray
varenicline
OC-01
dry eye disease
pharmacokinetics
semi-PBPK model
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.910629/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.910629/full

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