Peficitinib inhibits fibroblast-like synoviocyte activation and angiogenic vascular endothelial tube formation via inhibitory effects on PDGF and VEGF signaling in addition to JAK

Peficitinib inhibits fibroblast-like synoviocyte activation and angiogenic vascular endothelial tube formation via inhibitory effects on PDGF and VEGF signaling in addition to JAK

Purpose: Peficitinib and tofacitinib are known to suppress inflammation in rheumatoid arthritis (RA) by inhibiting Janus kinases (JAKs). However, these effects on tyrosine kinases other than JAKs have not yet been well investigated. We evaluated the effects of peficitinib and tofacitinib on platelet...

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Bibliographic Details
Main Authors: Go Ishikawa, Chulwon Kwon, Yasutomo Fujii
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Journal of Pharmacological Sciences
Subjects:
Peficitinib
Tofacitinib
Platelet-derived growth factor
Vascular endothelial growth factor
Rheumatoid arthritis
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861322000524

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http://www.sciencedirect.com/science/article/pii/S1347861322000524

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