Blocking the CGRP Receptor: Differences across Human Vascular Beds

Blocking the CGRP Receptor: Differences across Human Vascular Beds

Multiple drugs targeting the calcitonin gene-related peptide (CGRP) receptor have been developed for the treatment of migraine. Here, the effect of the small-molecule CGRP receptor antagonist zavegepant (0.1 nM–1 µM) on CGRP-induced relaxation in isolated human coronary arteries (HCAs) was investiga...

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Bibliographic Details
Main Authors: Tessa de Vries, Deirdre M. Boucherie, Antoon van den Bogaerdt, A. H. Jan Danser, Antoinette MaassenVanDenBrink
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Pharmaceuticals
Subjects:
antagonism
CGRP
gepants
migraine
potency
Schild plot
Online Access:https://www.mdpi.com/1424-8247/16/8/1075

Internet

https://www.mdpi.com/1424-8247/16/8/1075

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