A Monoclonal Human Alveolar Epithelial Cell Line (“Arlo”) with Pronounced Barrier Function for Studying Drug Permeability and Viral Infections

A Monoclonal Human Alveolar Epithelial Cell Line (“Arlo”) with Pronounced Barrier Function for Studying Drug Permeability and Viral Infections

Abstract In the development of orally inhaled drug products preclinical animal models regularly fail to predict pharmacological as well as toxicological responses in humans. Models based on human cells and tissues are potential alternatives to animal experimentation allowing for the isolation of ess...

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Bibliographic Details
Main Authors: Patrick Carius, Annemarie Jungmann, Marco Bechtel, Alexander Grißmer, Annette Boese, Gilles Gasparoni, Abdulrahman Salhab, Ralf Seipelt, Klaus Urbschat, Clémentine Richter, Carola Meier, Denisa Bojkova, Jindrich Cinatl, Jörn Walter, Nicole Schneider‐Daum, Claus‐Michael Lehr
Format: Article
Language:English
Published: Wiley 2023-03-01
Series:Advanced Science
Subjects:
drug transport
lung
pulmonary drug delivery
tight junctions
Transwell inserts
Online Access:https://doi.org/10.1002/advs.202207301

Internet

https://doi.org/10.1002/advs.202207301

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