A Mixed-chimerism Protocol Utilizing Thymoglobulin and Belatacept Did Not Induce Lung Allograft Tolerance, Despite Previous Success in Renal Allotransplantation

A Mixed-chimerism Protocol Utilizing Thymoglobulin and Belatacept Did Not Induce Lung Allograft Tolerance, Despite Previous Success in Renal Allotransplantation

Background. In kidney transplantation, long-term allograft acceptance in cynomolgus macaques was achieved using a mixed-chimerism protocol based on the clinically available reagents, rabbit anti-thymocyte globulin (ATG), and belatacept. Here, we have tested the same protocol in cynomolgus macaques t...

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Bibliographic Details
Main Authors: Wiebke Sommer, MD, Jane M. O, MD, Kurt B. Pruner, BSc, Abbas Dehnadi, DVM, Kyu Ha Huh, MD, Kortney A. Robinson, MD, Isabel Hanekamp, PhD, Ivy Rosales, MD, Alison S. Bean, BSc, Josh Paster, BSc, Tetsu Oura, MD, Rex Neal Smith, MD, Robert Colvin, MD, Gilles Benichou, PhD, Tatsuo Kawai, MD, Joren C. Madsen, MD, DPhil, James S. Allan, MD
Format: Article
Language:English
Published: Wolters Kluwer 2021-06-01
Series:Transplantation Direct
Online Access:http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001150

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http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001150

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