Trabecular Bone Deficit and Enhanced Anabolic Response to Re-Ambulation after Disuse in Perlecan-Deficient Skeleton

Trabecular Bone Deficit and Enhanced Anabolic Response to Re-Ambulation after Disuse in Perlecan-Deficient Skeleton

Perlecan/Hspg2, a large monomeric heparan sulfate proteoglycan, is found in the basement membrane and extracellular matrix, where it acts as a matrix scaffold, growth factor depot, and tissue barrier. Perlecan deficiency leads to skeletal dysplasia in Schwartz-Jampel Syndrome (SJS) and is a risk fac...

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Bibliographic Details
Main Authors: Ashutosh Parajuli, Shaopeng Pei, Hongbo Zhao, Jerahme R. Martinez, X. Lucas Lu, X. Sherry Liu, Mary C. Farach-Carson, Catherine B. Kirn-Safran, Liyun Wang
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Biomolecules
Subjects:
perlecan
schwartz-jampel syndrome
trabecular bone
osteoporosis
osteoclastogenesis
hindlimb suspension
re-ambulation
micro-computed tomography
Online Access:https://www.mdpi.com/2218-273X/10/2/198

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https://www.mdpi.com/2218-273X/10/2/198

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