Suppression of glycogen synthesis as a treatment for Lafora disease: Establishing the window of opportunity

Suppression of glycogen synthesis as a treatment for Lafora disease: Establishing the window of opportunity

Abstract.Lafora disease (LD) is a fatal adolescence-onset neurodegenerative condition. The hallmark of LD is the accumulation of aberrant glycogen aggregates called Lafora bodies (LBs) in the brain and other tissues. Impeding glycogen synthesis from early embryonic stages by genetic suppression of g...

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Bibliographic Details
Main Authors: Olga Varea, Jordi Duran, Mònica Aguilera, Neus Prats, Joan J. Guinovart
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Neurobiology of Disease
Subjects:
Lafora disease
Glycogen
Brain aggregates
Glycogen synthase
Astrogliosis
Neuroinflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120304484

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http://www.sciencedirect.com/science/article/pii/S0969996120304484

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